High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv
نویسندگان
چکیده
منابع مشابه
Designing of inhibitors against drug tolerant Mycobacterium tuberculosis (H37Rv)
BACKGROUND Mycobacterium tuberculosis (M.tb) is the causative agent of tuberculosis, killing ~1.7 million people annually. The remarkable capacity of this pathogen to escape the host immune system for decades and then to cause active tuberculosis disease, makes M.tb a successful pathogen. Currently available anti-mycobacterial therapy has poor compliance due to requirement of prolonged treatmen...
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Mycobacterium tuberculosis H(37)Rv is a highly successful pathogen and its success fully relies on its ability to utilize macrophages for its replication and, more importantly, the macrophage should remain viable to host the Mycobacterium. Despite the fact that these phagocytes are usually very effective in internalizing and clearing most of the bacteria, M. tuberculosis H(37)Rv has evolved a n...
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There is an error in the second sentence of the second paragraph within the Introduction. The correct sentence is: DnaE2 belongs to the C family of error prone DNA polymerases that has been reported to be responsible for pathogen survival and drug resistance [6]. There is an error in reference 6. The author names are listed incorrectly. The correct reference is: Boshoff HI, Reed MB, Barry CE 3r...
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ژورنال
عنوان ژورنال: Tuberculosis
سال: 2009
ISSN: 1472-9792
DOI: 10.1016/j.tube.2009.05.008